Leptospirosis is often described as a neglected but emerging zoonotic disease. In this hour we will explore the natural history of leptospirosis to learn why everyone, everywhere should care and then discover some common and unexpected disease manifestations, primarily focused on dogs but with a little about cats. We will also discuss the different diagnostic tests currently available, including the microscopic agglutination test, polymerase chain reaction assay and point-of-care ELISAs. Therapy for leptospirosis is both supportive and anti-leptospiral specific, but for most veterinarians that means ampicillin and doxycycline. We’ll discuss a variety of considerations in supportive care and a surprising link to Covid. We will also discuss standard and optional antibiotic therapy and how to monitor the success of therapy (and why you should be monitoring the success of therapy). We’ll conclude with a brief discussion on prevention and dealing with the infected dog at home.